Hemodynamics, fluids & transfusion
The effect of plasma versus crystalloids on intravascular volume, tissue perfusion and tissue oxygenation: a randomized controlled trial in a human endotoxemia model
Authors' conclusion
In healthy endotoxemic volunteers without shock, plasma infusion augmented intravascular blood volume and cardiac output, resulting in improved microcirculatory tissue perfusion compared to crystalloids. However, plasma did not restore the reduction in skin mitoPO2 as much as crystalloids.
Study context
- Population
- Healthy volunteers given 2 ng/kg lipopolysaccharide (LPS) infusion
- Participants
- 12 participants
- Comparison
- Plasma 10 ml/kg vs balanced crystalloids 10 ml/kg
- Plasman = 6
Methodological detailshuman endotoxemia model
- Human endotoxemia model
Primary result
As reported in the abstract
Intravascular volume (estimated from hemoglobin levels) · one hour after infusion
- Plasma increased intravascular volume by 4 ml/kg; intravascular volume remained at baseline with crystalloids
- Plasma vs Crystalloids: P < 0.01
Original publication
The effect of plasma versus crystalloids on intravascular volume, tissue perfusion and tissue oxygenation: a randomized controlled trial in a human endotoxemia model. Crit Care. Published 24 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →