Pediatric anesthesia & critical care
Cerebral Autoregulation During Antegrade Cerebral Perfusion in Neonates Undergoing Congenital Cardiac Surgery
Authors' conclusion
This study demonstrated that a minority of the neonates examined retained the ability to autoregulate during ACP. Hypotension below LLA is associated with impaired autoregulation during ACP.
Study context
- Population
- Neonates undergoing aortic arch reconstruction with antegrade cerebral perfusion (ACP), August 2021–January 202558 unique patients
- Participants
- 59 neonates
- Exposure
- Intact vs impaired cerebral vasoreactivity during ACP
- Intact autoregulationn = 17
- Outcome
- Hemoglobin Volume Index (HVx): moving Pearson correlation between mean arterial blood pressure (ABP) and regional total hemoglobin (NIRS); LLA by HVx cutoff ≥0.2
- Follow-up
- During ACP
Methodological detailssingle-centre, university hospital, Median age 5 days (IQR 3, 9); ACP time 61 minutes (IQR 47, 77)
- Single-centre
- University hospital
- Median age 5 days (IQR 3, 9); ACP time 61 minutes (IQR 47, 77)
Main finding
As reported in the abstract
Intact cerebral vasoreactivity during ACP; LLA
Intact autoregulation
28.8%
17
Observational data: associations, not effects.
Further findings
Hypotension during ACP (LLA − ABP during ACP) · significantly less hypotension with intact autoregulation
P = 0.022
Original publication
Cerebral Autoregulation During Antegrade Cerebral Perfusion in Neonates Undergoing Congenital Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 10 July 2026. doi:10.
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