Pediatric anesthesia & critical care
Intraoperative Assessment of Cerebral Autoregulation With Cerebral Oximetry Index in Neonates Undergoing Cardiac Surgery: A Pilot Study
Authors' conclusion
Cerebral autoregulation was impaired during CPB and remained altered after separation from bypass.
Study context
- Population
- Term neonates undergoing surgery for critical congenital heart defects, single-centre university children's hospital
- Participants
- 16 term neonates
- Exposure
- COx before vs during vs after cardiopulmonary bypass (CPB)
- Outcome
- COx
Methodological detailssingle-centre, pilot
- Single-centre
- Pilot
Main finding
As reported in the abstract
Pre-CPB
0.02
median · IQR −0.08–0.13
During CPB
0.34
median · IQR 0.18–0.43
Post-CPB
0.26
median · IQR 0.05–0.38
Observational data: associations, not effects.
Further findings
Associations of intraoperative COx evolution
- Linearly associated with changes in cerebral oximetry, pO2 and core temperature but not with MAP and pCO2
- Linear mixed-effects model
Intraoperative limits of autoregulation (COx cut-off 0.3), entire cohort
mmHg
- Lower limit
- 35
- Upper limit
- 59
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intraoperative Assessment of Cerebral Autoregulation With Cerebral Oximetry Index in Neonates Undergoing Cardiac Surgery: A Pilot Study. J Cardiothorac Vasc Anesth. Published 18 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →