Pediatric anesthesia & critical care
Perioperative Incidence of Acute Renal Failure in Aortic Arch Reconstruction Using Retrograde Selective Lower Body Perfusion in Neonates and Infants
Authors' conclusion
Retrograde SLP is associated with a reduced AKI incidence and increased postoperative urine output, without vascular complications.
Study context
- Population
- Neonates and infants undergoing elective aortic arch reconstruction with CPB, pediatric heart centre of a tertiary care hospital, 2015–2023
- Participants
- 104 neonates
- Exposure
- Retrograde SLP via femoral artery catheter vs no SLP
- SLPn = 45
- Outcome
- Perioperative acute kidney injury (AKI) incidence (KDIGO criteria) and urine output
- Follow-up
- Multiple predetermined time points
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AKI incidence · immediately and 6 hours postsurgery
- SLP vs Control: P = 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| Postoperative urine output · until day 3Higher urine output in SLP | P ≤ 0.045 |
Safety
Vascular complications · until hospital discharge
- No vascular complications observed
Original publication
Perioperative Incidence of Acute Renal Failure in Aortic Arch Reconstruction Using Retrograde Selective Lower Body Perfusion in Neonates and Infants. J Cardiothorac Vasc Anesth. Published 21 March 2025. doi:10.
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