Pediatric anesthesia & critical care
Change to Mixed-Lipid Emulsion From Soybean Oil–Based Lipid Emulsion in Pediatric Patients
Authors' conclusion
In this observational study of clinical outcomes among children dependent on PN, a switch to 4-OLE in a large academic hospital was associated with a significant decrease in hospital LOS in ICU and non-ICU patients.
Study context
- Population
- Pediatric patients aged 1 month to 17 years requiring parenteral nutrition (PN), large US academic referral center, May 2016 to September 2019342 critically ill
- Participants
- 684 patients
- Exposure
- Mixed-lipid emulsion vs pure soybean oil-based lipid emulsions (LE)
- 4-OLEn = 478
- ILn = 206reference
- Outcome
- Hospital length of stay (LOS)
Methodological detailssingle-centre, before-after hospital-wide switch, multivariable regression, Data analyzed from October 2020 to February 2023
- Single-centre
- Before-after hospital-wide switch
- Multivariable regression
- Data analyzed from October 2020 to February 2023
Main finding
As reported in the abstract
4-OLE vs ILIncidence rate ratio (95% CI)
ICU cohort
0.81(0.78–0.83)
- All children cohort
- IRR 0.81 (95% CI 0.05–0.78)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | |
|---|---|---|
| UTI risk4-OLE vs IL · all children cohort | 0.33 (0.18–0.64) | |
| UTI risk4-OLE vs IL · ICU cohort | 0.23 (0.11–0.51) | |
| 0.10.31310Odds ratio (log scale) |
Other secondary outcomes (mortality, readmission, pneumonia, caloric delivery, liver function tests)
- Other secondary outcomes were not significant
Original publication
Change to Mixed-Lipid Emulsion From Soybean Oil–Based Lipid Emulsion in Pediatric Patients. JAMA Netw Open. Published 5 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →