Respiratory failure & ventilation
Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity
Authors' conclusion
In mechanically ventilated patients with ARDS and obesity, supine posture provided lower lung and chest wall elastance, and better CO2 clearance, than the semi-recumbent posture.
Study context
- Population
- Mechanically ventilated patients with ARDS with and without obesity
- Participants
- 40 consecutive patients
- Comparison
- Supine-flat (0°) vs semi-recumbent (40° head up) trunk inclination, in patients with ARDS with vs without obesity
- Obesen = 20
- Non-obesen = 20reference
- Primary endpoint
- Partition respiratory mechanics, airway opening pressure and arterial blood gases, supine-flat vs semi-recumbent
- Follow-up
- End of each 15-minute step
Methodological detailssingle-centre, randomised order of posture steps
- Single-centre
- Randomised order of posture steps
Primary result
As reported in the abstract
Partition respiratory mechanics and blood gases, supine vs semi-recumbent
- Obese: lung and chest wall elastance, driving pressure, inspiratory transpulmonary pressure, PaCO2 and ventilatory ratio lower supine than semi-recumbent
- P < .001
- Obese: airways resistance greater supine
- P = .006
- Non-obese: only chest wall elastance lower supine vs semi-recumbent
- P < .001
Original publication
Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity. Chest. Published 11 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →