Respiratory failure & ventilation
Respiratory effects of trunk inclination in obese and non-obese patients mechanically ventilated for ARDS
Authors' conclusion
Increasing the trunk inclination angle during passive ventilation reduces respiratory system, lung, and chest wall compliance. This effect was more pronounced in obese patients. Moreover, only this population exhibited an increase in PaCO2.
Study context
- Population
- Mechanically ventilated patients with ARDS
- Participants
- 159 participants · 7 studies
- Comparison
- Obese vs Non-obese
- Obesen = 65
- Non-obesen = 94reference
Methodological detailspooled data from seven individual studies, Methodological heterogeneity across the included studies
- Pooled data from seven individual studies
- Methodological heterogeneity across the included studies
Primary result
As reported in the abstract
Change in respiratory system compliance with increased trunk inclination
- Greater decrease in respiratory system compliance in patients with obesity
Further findings
| Outcome | Obese | Non-obese |
|---|---|---|
| Change in lung compliance | −7.8 (interval −12.4–-3.3) mL/cmH2O | −5.9 (interval −14.2–2.3) mL/cmH2O |
| p | p < 0.001 | p = 0.160 |
| Change in chest wall compliance | −42.9 (interval −63.2–-22.6) mL/cmH2O | −47.7 (interval −95.3–-0.15) mL/cmH2O |
| p | p < 0.001 | p = 0.049 |
| Change in PaCO2 | 4.6 (interval 1.4–7.8) mmHg | 2.5 (interval −0.6–5.6) |
| p | p = 0.004 | p = 0.113 |
PaO2/FIO2
- No significant differences between phases
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Respiratory effects of trunk inclination in obese and non-obese patients mechanically ventilated for ARDS. Crit Care. Published 28 October 2025. doi:10.
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