Changes in velocimetric indices of uterine and umbilical arteries before and after combined spinal epidural analgesia in laboring women: a prospective cohort study
Authors' conclusion
Our study suggests that CSE for labor analgesia may be associated with a discrete increase in maternal UtA resistance, however, these changes are not reflected in UmA resistance in the fetus
Study context
- Population
- Singleton, full-term laboring women receiving combined spinal epidural (CSE) labor analgesiaanalysed
- Participants
- 30 participants
- Exposure
- Doppler pulsatility index (PI) after vs before CSE labour analgesia
- Outcome
- Doppler PI of the UtA and UmA
- Follow-up
- 10 min
Methodological detailsobservational, before-after
- Observational
- Before-after
Main finding
As reported in the abstract
PI at 10 min vs baseline
- Significant increase in mean UtA PI vs baseline (Δ 27 %)
- P = 0.029
Observational data: associations, not effects.
Further findings
Change in PI over time (mixed models, exploratory)
- UtA PI significant increase over time (coefficient 0.05)
- P = 0.002
- No changes in umbilical arteries (UmA) PI
- Exploratory analyses
Safety
- No changes in fetal heart rate
Original publication
Changes in velocimetric indices of uterine and umbilical arteries before and after combined spinal epidural analgesia in laboring women: a prospective cohort study. Int J Obstet Anesth. Published 5 September 2025. doi:10.
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