Characteristics and Outcomes of Viral Sepsis: A Retrospective Study
Authors' conclusion
In an adult population meeting Sepsis-3 criteria and negative for other organisms, 3.3% of patients had viral sepsis with 90-day mortality of 15%. Antiviral medicines were not associated with better survival.
Study context
- Population
- Adults with sepsis by Sepsis-3 criteria, excluding positive nonviral culturesafter excluding positive nonviral cultures
- Participants
- 31,109 adults
- Exposure
- Viral sepsis vs nonviral sepsis
- Viral sepsisn = 1,034
- Outcome
- Prevalence of viral sepsis and 90-day mortality
- Follow-up
- 90 days
Methodological detailshospital database study
- Hospital database study
Main finding
As reported in the abstract
Prevalence of viral sepsis and 90-day mortality Viral sepsis 3.3%
90-day mortality
Observational data: associations, not effects.
Further findings
Factors associated with mortality (adjusted)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Initiation of mechanical ventilation after sepsis onsetAfter adjustment | 3.142 (1.692–5.836) | P < 0.001 | |
| Severity of sepsis (SOFA score)After adjustment | 1.159 (1.051–1.278) | P = 0.004 | |
| Lactate levelsAfter adjustment | 1.204 (1.085–1.337) | P < 0.001 | |
| Receipt of antiviral medicationsNot associated with improved survival · after adjustment | 1.160 (0.142–9.449) | P = 0.875 | |
| 0.10.31310Odds ratio (log scale) |
- Factors associated with mortality (adjusted) — Model discrimination
- 0.845 ± 0.017
- Factors associated with mortality (adjusted) — Model relevance
- 0.518
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Characteristics and Outcomes of Viral Sepsis: A Retrospective Study. Anesth Analg. Published 9 September 2026. doi:10.
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