Pediatric anesthesia & critical care
Viral DNAemia and DNA Virus Seropositivity and Mortality in Pediatric Sepsis
An erratum to this article was published (JAMA Netw Open, 4 Mar 2024 ↗)
Authors' conclusion
The findings of this cohort study suggest that DNAemia for CMV, HAdV, BKPyV, and HHV-6 and EBV seropositivity were independently associated with increased sepsis mortality.
Study context
- Population
- Patients younger than 18 years with severe sepsis in 9 pediatric intensive care units (PICUs) of the NICHD Collaborative Pediatric Critical Care Research Network, 2015–2018
- Participants
- 401 participants
- Exposure
- DNAemia vs No DNAemia
- DNAemian = 191
- Outcome
- Death while in the PICU
Methodological details9 PICUs, Data collected 2015–2018; samples assayed 2019–2022; analysed 2022–2023
- 9 PICUs
- Data collected 2015–2018; samples assayed 2019–2022; analysed 2022–2023
Main finding
As reported in the abstract
- Overall PICU deaths
- 44 (11.0%)
Observational data: associations, not effects.
Further findings
Death in the PICU by Epstein-Barr virus (EBV) seropositivity
| aOR (95% CI) | P value | ||
|---|---|---|---|
| EBV seropositivity | 6.10 (1.00–118.61) | P = 0.049 | |
| 0.050.21520Adjusted odds ratio (log scale) |
- Death in the PICU by EBV seropositivity: additional adjustment for receipt of blood products in the PICU
Viral DNAemia with ≥1 virus (excluding torque teno virus (TTV))
- Overall
- 191 (47.6%)
- Immunocompromised
- 63 of 108 (58.3%)
- Not immunocompromised
- 128 of 293 (43.7%)
≥2 viruses detected, and mortality (subgroup)
- ≥2 viruses detected
- 78 (19.5%)
- Mortality, immunocompromised
- 12 of 32 (37.5%)
- Mortality, not immunocompromised
- 9 of 46 (19.6%)
Herpesvirus seropositivity
- HSV-1
- 82 of 246 [33.3%]
- Cytomegalovirus (CMV)
- 107 of 254 [42.1%]
- EBV
- 152 of 251 [60.6%]
- HHV-6
- 253 if 257 [98.4%]
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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