Pediatric anesthesia & critical care
Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure
Authors' conclusion
Elevated sICAM-1 levels were associated with poor outcomes in two separate cohorts of ARDS and ARF patients. Network analysis revealed sICAM-1 as a central hub, characterized by high centrality metrics.
Study context
- Population
- Critically ill children with acute respiratory distress syndrome (ARDS) or acute respiratory failure (ARF) in multicentre PICUstwo cohorts
- Participants
- 214 vs 251
- Comparison
- Higher vs lower plasma sICAM-1 levels
- PALIn = 214
- CAF-PINTn = 251
- Primary endpoint
- In-hospital mortality
Methodological detailsmulticentre, biomarker network analysis, sICAM-1 measured in plasma collected within 72 hours of diagnosis
- Multicentre
- Biomarker network analysis
- sICAM-1 measured in plasma collected within 72 hours of diagnosis
Primary result
As reported in the abstract
- Higher plasma sICAM-1 associated with in-hospital mortality in each cohort
- P < 0.05
Secondary outcomes
Multiple organ dysfunction and ventilator-free days (secondary outcomes)
- Higher plasma sICAM-1 associated with multiple organ dysfunction and fewer ventilator-free days in each of the two cohorts
- all p < 0.05
Biomarker network hubs (composite centrality)
- Tissue inhibitor of metalloproteinase-1
- 0.99
- Tumor necrosis factor receptor-1
- 0.83
- sICAM-1
- 0.74
- Interleukin-8
- 0.74
- Hubs = centrality metrics in the top 10% (≥ 90th percentile)
Original publication
Plasma Soluble Intercellular Adhesion Molecule-1 Has a Central Role in Biomarker Network Analysis and Is Associated With Poor Outcomes in Two Distinct Pediatric Cohorts of Acute Respiratory Distress Syndrome and Acute Respiratory Failure. Crit Care Med. Published 3 June 2025. doi:10.
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