Pediatric anesthesia & critical care
Early, Persistent Lymphopenia Is Associated With Prolonged Multiple Organ Failure and Mortality in Septic Children
Main finding · Prolonged MODS or PICU mortalityResult — go to the resultOdds ratio 2.98 95% CI 1.85–4.02Authors' conclusion
Children with severe sepsis and persistent lymphopenia are at risk of prolonged MODS or PICU mortality.
Study context
- Population
- Children with severe sepsis and indwelling arterial and/or central venous catheters, 9 PICUs of the NIH Collaborative Pediatric Critical Care Research Network, 2015–2017
- Participants
- 401 children
- Exposure
- Early, persistent lymphopenia vs no persistent lymphopenia
- Persistent lymphopenian = 152
- Withoutn = 249reference
- Outcome
- Prolonged multiple organ dysfunction syndrome (MODS) or PICU mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Odds ratio
2.98
95% CI 1.85–4.02
P < 0.01
Events by group
Persistent lymphopenia vs Without
OR 2.98 (95% CI 1.85–4.02); P < 0.01
Observational data: associations, not effects.
Further findings
Prolonged MODS
PICU mortality
P < 0.01
Lymphocyte trajectories, TNF-α response and inflammatory markers (days 0-3)
- Persistent lymphopenia: generally no lymphocyte recovery, lower nadir whole blood TNF-α response to LPS, higher maximal CRP and ferritin
- P < 0.01
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early, Persistent Lymphopenia Is Associated With Prolonged Multiple Organ Failure and Mortality in Septic Children. Crit Care Med. Published 18 July 2023. doi:10.
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