Cardiothoracic & vascular anesthesia
Characteristics Associated with Mortality in 623 Patients Who Received Recombinant Factor VIIa for Bleeding in Cardiac Surgery
Authors' conclusion
rFVIIa can be administered to cardiac surgical patients with characteristics associated with mortality that are similar to cardiac surgical patients who did not receive rFVIIa.
Study context
- Population
- Cardiac surgery patients who received very-low-dose rFVIIa for nonsurgical bleeding, January 2012 to January 2025of 7,724 cardiac surgery patients
- Participants
- 623 patients
- Exposure
- Survivors vs Nonsurvivors
- Survivorsn = 557reference
- Nonsurvivorsn = 66
- Outcome
- Mortality
Methodological detailssingle tertiary care hospital, Average rFVIIa dose 18 μg/kg (min-max, 6-55 μg/kg), given perioperatively in 0.5- to 1-mg aliquots
- Single tertiary care hospital
- Average rFVIIa dose 18 μg/kg (min-max, 6-55 μg/kg), given perioperatively in 0.5- to 1-mg aliquots
Main finding
As reported in the abstract
- Deaths among rFVIIa recipients
- 66
- Procedure type associated with mortality
- p = 0.004
- Mortality, heart transplant, ventricular assist device or other complex procedure
- 29.5%
- Mortality, aortic procedures (n = 250)
- 12.4%
- Higher mortality with emergent or urgent surgery
- p < 0.001
- Higher mortality with preoperative cardiogenic shock
- p = 0.021
- Higher mortality with longer CPB time
- p = 0.005
- Higher mortality with postoperative cardiac arrest
- p = 0.001
- Higher mortality with more blood products
- p < 0.001
- No association of mortality with stroke
- p = 0.071
- No association of mortality with infections
- p = 1.00
Observational data: associations, not effects.
Further findings
Median rFVIIa dose · described as not different
P = 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Characteristics Associated with Mortality in 623 Patients Who Received Recombinant Factor VIIa for Bleeding in Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 21 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →