Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study
Authors' conclusion
New-onset QT prolongation in sepsis was associated with increased mortality as well as atrial and ventricular arrhythmias, which was predicted by disease severity and organ dysfunction.
Study context
- Population
- Patients with sepsis from wards and ICUs of four centers, after exclusion of QT-influencing medications and electrolyte abnormalities
- Participants
- 1,024 patients · 4 centers
- Exposure
- QT prolongation vs no QT prolongation
- QT prolongationn = 235
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
New-onset QT prolongation and 30-day in-hospital mortality
- New-onset QT prolongation incidence
- 235/1024 (22.9%)
- Higher 30-day in-hospital mortality with QT prolongation
- P < 0.001
- QT prolongation independently predicted 30-day mortality (multivariate analysis)
- P = 0.044
Observational data: associations, not effects.
Further findings
Tachyarrhythmias during hospitalization
- Increased paroxysmal AF or tachycardia with QT prolongation
- P < 0.001
- Increased ventricular arrhythmia with QT prolongation
- P < 0.001
Independent predictors of QT prolongation
- History of coronary artery disease
- P = 0.001
- Septic shock
- P = 0.008
- Acute respiratory dysfunction
- P < 0.001
- Acute heart dysfunction
- P = 0.021
- Acute renal dysfunction
- P = 0.013
QT prolongation pattern
- Majority similar pattern to type 1 long QT syndrome
Original publication
Characteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study. Crit Care. Published 9 April 2024. doi:10.
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