Characterization of the temporal profile of the antinociceptive effects of an intravenous bolus of ketamine using the analgesia nociception index in no-anesthetized adult patients
Authors' conclusion
The developed PKPD model, using Domino's PK parameters and the ANI response data, adequately characterized the temporal profile of ketamine's antinociceptive effect.
Study context
- Population
- Awake adult patients before GA, without other drugs affecting the analgesia nociception index (ANI) response
- Participants
- 20 patients
- Outcome
- PKPD model of ketamine antinociceptive effect (Domino PK parameter set and ANI response)
Methodological detailsprospective, single-group
- Prospective
- Single-group
Main finding
As reported in the abstract
PKPD model parameters and ANI response
| Group | Value | Basal ANI | Maximum ANI | Observed time-to-peak effect | Estimated Ke0 |
|---|---|---|---|---|---|
| Ketamine | mean 38.5 (SD 4.95) | 38.5 ± 4.95 | 53.5 ± 4.95 | 1.83 ± 0.74 min | 0.238 (CI95% 0.20-0.28) min-1 |
Ketamine
Valuemean 38.5 (SD 4.95)
Basal ANI38.5 ± 4.95
Maximum ANI53.5 ± 4.95
Observed time-to-peak effect1.83 ± 0.74 min
Estimated Ke00.238 (CI95% 0.20-0.28) min-1
Observational data: associations, not effects.
Original publication
Characterization of the temporal profile of the antinociceptive effects of an intravenous bolus of ketamine using the analgesia nociception index in no-anesthetized adult patients. J Clin Monit Comput. Published 15 November 2024. doi:10.
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