Pediatric anesthesia & critical care
Nociception level response to calibrated stimulations in children: First assessment of the nociception level index in pediatric anesthesia
Authors' conclusion
NOL allows a quantitative assessment of nociception under anesthesia in 5-12 years-old children.
Study context
- Population
- Children 5–12 years old anesthetized with sevoflurane and alfentanil (10 µg kg-1), before surgical incision
- Participants
- 30 children
- Comparison
- Tetanic stimulations of 10, 30 and 60 mA
- Outcome
- NOL variation after calibrated tetanic stimulations
Methodological detailsrandomized order of stimulation intensities
- Randomized order of stimulation intensities
Main finding
As reported in the abstract
NOL response
- Nociception Level (NOL) increased after the stimulations at each intensity
- p < 0.05
- NOL response influenced by stimulation intensity
- p < 0.001
Further findings
Heart rate and BP
- Barely modified by the stimulations
Analgesia-Nociception Index
- Decreased after the stimulations at each intensity
- P < 0.001
- Response not influenced by stimulation intensity
- P = 0.064
Correlation of NOL and Analgesia-Nociception Index responses
- Pearson r
- 0.47
- P
- P < 0.001
Original publication
Nociception level response to calibrated stimulations in children: First assessment of the nociception level index in pediatric anesthesia. Anaesth Crit Care Pain Med. Published 1 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →