Perioperative medicine & outcomes
Chewing Gum to Treat Postoperative Nausea and Vomiting in Female Patients: A Multicenter Randomized Trial
Primary resultResult — go to the resultAbsolute risk difference −17.3 % 95% CI −30.4 to −4.3Authors' conclusion
Chewing gum cannot be recommended as an alternative to ondansetron for treatment of postoperative nausea and vomiting in female patients administered antiemetic prophylaxis.
Study context
- Population
- Female patients aged 12 yr or older with PONV in PACU after volatile anaesthetic-based GA for laparoscopic or breast surgery, with protocolised antiemetic prophylaxis865 enrolled
- Participants
- 218 patients
- Comparison
- Chewing gum vs IV ondansetron for treatment of PONV in PACU
- Chewing gumn = 103
- Ondansetronn = 105reference
- Primary endpoint
- Complete response: cessation of nausea, retching or vomiting with no recurrence nor rescue medication
- Follow-up
- 2 h after the randomised intervention
Methodological detailsmulticentre, noninferiority, 17 hospitals in Australia and New Zealand
- Multicentre
- Noninferiority
- 17 hospitals in Australia and New Zealand
Primary result
As reported in the abstract
Absolute risk difference
−17.3 %
95% CI −30.4 to −4.3
Events by treatment group
Chewing gum vs Ondansetron
absolute risk difference −17.3 % (95% CI −30.4 to −4.3)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Time to complete responseLonger with chewing gum | 0.53 (0.34–0.83) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Absolute risk difference (%) (95% CI) | |
|---|---|---|
| Antiemetics received · 24 h after surgeryMore likely with chewing gum | 14.1 (1.6–26.5) | |
| −2002040Difference, % (linear scale) |
Original publication
Chewing Gum to Treat Postoperative Nausea and Vomiting in Female Patients: A Multicenter Randomized Trial. Anesthesiology. Published 30 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →