Perioperative medicine & outcomes
The safety of perioperative dexamethasone with antiemetic dosage in surgical patients with diabetes mellitus: a systematic review and meta-analysis
Authors' conclusion
Dexamethasone could increase blood glucose by only 2.014 mmol/L (36.252 mg/dL) of peak glucose level within 24 hours of surgery in surgery patients with DM, the increase of glucose level at each time point perioperatively was even lower, and had no effect on wound healing.
Study context
- Population
- Surgical patients with diabetes mellitus (DM)9 randomized controlled trials (RCTs) and 7 cohort studies
- Comparison
- Single-dose IV dexamethasone for postoperative nausea and vomiting (PONV) prophylaxis vs control
- Outcome
- Blood glucose level
Pooled result
As reported in the abstract
Dexamethasone vs ControlMD (95% CI)P value
Intraoperatively; I2 = 55.7%
0.439(0.137–0.581)
P = 0.004End of surgery; I2 = 73.5%
0.815(0.563–1.067)
P = 0.000POD 1; I2 = 88%
1.087(0.534–1.640)
P = 0.000POD 2; I2 = 0%
0.501(0.301–0.701)
P = 0.000Peak glucose within 24 hours of surgery; I2 = 91.6%
2.014(0.503–3.525)
P = 0.009- Increase in perioperative glucose at different time points vs control
- 0.439 to 1.087 mmol/L (7.902 to 19.566 mg/dL)
- Increase in peak glucose within 24 hours of surgery vs control
- 2.014 mmol/L (36.252 mg/dL)
Safety
- No impact on wound healing
- P < 0.05 as printed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The safety of perioperative dexamethasone with antiemetic dosage in surgical patients with diabetes mellitus: a systematic review and meta-analysis. Perioper Med (Lond). Published 8 March 2023. doi:10.
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