Perioperative medicine & outcomes
Olanzapine as an add‐on, pre‐operative anti‐emetic drug for postoperative nausea or vomiting: a randomised controlled trial
Primary resultResult — go to the resultRelative risk 0.40 95% CI 0.21–0.79Authors' conclusion
Adding pre-operative oral olanzapine to intra-operative dexamethasone and ondansetron was highly effective in reducing the risk of postoperative nausea or vomiting in the first 24 hours after surgery in patients with a previous history of chemotherapy-induced nausea and vomiting and at least three Apfel risk factors for postoperative nausea or vomiting.
Study context
- Population
- Patients aged 18–60 years with cancer at high PONV risk (3 or 4 Apfel risk factors) and previous chemotherapy-induced nausea and vomitingenrolled
- Participants
- 100 patients
- Comparison
- Olanzapine vs Control
- Olanzapinen = 47
- Controln = 49reference
- Primary endpoint
- Incidence of PONV
- Follow-up
- First 24 h after surgery
Methodological detailsmultiply-blinded, placebo-controlled
- Multiply-blinded
- Placebo-controlled
Primary result
As reported in the abstract
Relative risk
0.40
95% CI 0.21–0.79
P = 0.008
Events by treatment group
Olanzapine vs Control
RR 0.40 (95% CI 0.21–0.79); P = 0.008
Original publication
Olanzapine as an add‐on, pre‐operative anti‐emetic drug for postoperative nausea or vomiting: a randomised controlled trial. Anaesthesia. Published 14 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →