Perioperative medicine & outcomes
Preoperative Olanzapine and Quality of Recovery after Ambulatory Surgery: A Randomized Clinical Trial
Primary result · QoR-40Result — go to the resultDifference 9.0 points 95% CI 6.1–11.8Authors' conclusion
When combined with dexamethasone and ondansetron, a single preoperative dose of 5 mg olanzapine improved global quality of recovery after discharge from ambulatory surgery.
Study context
- Population
- Female patients 18 to 50 yr undergoing ambulatory surgery under GA
- Participants
- 384 patients
- Comparison
- Olanzapine vs Placebo
- Olanzapinen = 191
- Placebon = 193reference
- Primary endpoint
- QoR-40
- Follow-up
- POD 1
Methodological detailssingle-center, double-blind, placebo-controlled
- Single-center
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
Difference
9.0 points
95% CI 6.1–11.8
P < 0.001
Olanzapine vs Placebo
difference 9.0 points (95% CI 6.1–11.8); P < 0.001
Secondary outcomes
| Outcome | Difference (points) (95% CI) | P value | |
|---|---|---|---|
| QoR-40 · POD 2Significant after false discovery rate correction | 4.8 (2.0–7.6) | nominal P = 0.001 | |
| −50510Difference, points (linear scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Any nausea · POD 1 | 0.43 (0.28–0.66) | |
| Severe nausea · POD 1 | 0.26 (0.14–0.48) | |
| Any nausea · POD 2 | 0.48 (0.30–0.76) | |
| Severe nausea · POD 2 | 0.65 (0.30–1.40) | |
| 0.10.31310Odds ratio (log scale) |
PACU LOS
- Did not differ between groups
Original publication
Preoperative Olanzapine and Quality of Recovery after Ambulatory Surgery: A Randomized Clinical Trial. Anesthesiology. Published 20 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →