Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis
Authors' conclusion
Cholinesterase activities may be relevant prognostic markers for the occurrence of SAE and mortality in the ICU in patients with viral sepsis.
Study context
- Population
- Patients with viral or nonviral sepsis observed until intensive care unit (ICU) discharge, and healthy volunteers
- Participants
- 108 / 117 / 81
- Exposure
- Viral vs nonviral sepsis vs healthy volunteers
- Viral sepsisn = 108
- Nonviral sepsisn = 117
- Healthy volunteersn = 81reference
- Outcome
- AChE and BChE activities in whole blood as prognostic biomarkers of SAE and mortality
Main finding
As reported in the abstract
AChE and BChE activities · Three days after sepsis onset
| Group | Value | Butyrylcholinesterase (BChE) median [IQR] U·L-1 |
|---|---|---|
| Viral sepsis | median 5,105 (IQR 4,010–6,250) U·L-1 | 1,943 [1,393-2,468] |
| Nonviral sepsis | median 4,424 (IQR 3,630–5,055) U·L-1 | 1,095 [834-1,526] |
| Healthy volunteers | median 6,693 (IQR 5,401–8,020) U·L-1 | 2,645 [2,198-3,478] |
Value
Viral sepsismedian 5,105 (IQR 4,010–6,250) U·L-1
Nonviral sepsismedian 4,424 (IQR 3,630–5,055) U·L-1
Healthy volunteersmedian 6,693 (IQR 5,401–8,020) U·L-1
Butyrylcholinesterase (BChE) median [IQR] U·L-1
Viral sepsis1,943 [1,393-2,468]
Nonviral sepsis1,095 [834-1,526]
Healthy volunteers2,645 [2,198-3,478]
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| AChE activity, viral sepsis with vs without SAE during ICU stay (subgroup) · Three days after sepsis onset | SAE median 4,249 (IQR 3,798–5,351) U·L-1 · No SAE median 5,544 (IQR 4,124–6,461) U·L-1 |
| BChE activity, viral sepsis, died in ICU vs survived (subgroup) · Seven days after sepsis onset | Died median 1,427 (IQR 865–2,181) U·L-1 · Survived median 2,122 (IQR 1,571–2,787) U·L-1 |
Acetylcholinesterase (AChE) activity, viral sepsis with vs without sepsis-associated encephalopathy (SAE) during ICU stay (subgroup) · Three days after sepsis onset
- Lower AChE with SAE
BChE activity, viral sepsis, died in ICU vs survived (subgroup) · Seven days after sepsis onset
- Lower BChE in those who died
Original publication
Cholinesterase activities and sepsis-associated encephalopathy in viral versus nonviral sepsis. Can J Anaesth. Published 1 March 2024. doi:10.
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