Cardiothoracic & vascular anesthesia
Clinical Characteristics and Postoperative Outcomes of Bilateral Lung Transplantation for COVID-19–Induced End-Stage Pulmonary Disease: A Single-Center Experience in a High Acuity Patient Population
Authors' conclusion
The current study on BOLT for critically ill patients with end-stage lung disease secondary to COVID-19 infection provides additional information regarding the perioperative management of these patients and factors that may influence recovery trajectories in this high-risk population.
Study context
- Population
- Patients on prolonged extracorporeal membrane oxygenation (ECMO) for COVID-19-related end-stage lung disease undergoing bilateral orthotopic lung transplantation (BOLT), May 2020–April 2022; median lung allocation score 85.83
- Participants
- 37 patients
- Exposure
- Pulmonary hypertension vs No pulmonary hypertension
- Outcome
- Time from surgery to ECMO decannulation, time from BOLT to hospital discharge, and ICU duration
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Days to ECMO decannulation
P = 0.014
- Longer hospital stay associated with greater intraoperative cell saver
- P = 0.043
- Longer hospital stay associated with greater intraoperative 5% albumin
- P = 0.031
- Longer hospital stay associated with greater intraoperative 25% albumin
- P = 0.027
- Longer hospital stay associated with greater intraoperative packed RBC
- P = 0.015
Observational data: associations, not effects.
Further findings
Baseline cardiopulmonary status
- Right ventricular dysfunction
- 49%
- Pulmonary hypertension
- 41%
Original publication
Clinical Characteristics and Postoperative Outcomes of Bilateral Lung Transplantation for COVID-19–Induced End-Stage Pulmonary Disease: A Single-Center Experience in a High Acuity Patient Population. J Cardiothorac Vasc Anesth. Published 18 February 2026. doi:10.
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