Clinical Decision Support to Reduce Opioid Prescribing at Discharge for Inpatients Undergoing Surgery (LESS Study): An Interrupted Time Series Analysis
Main finding · Discharge oxycodone MMEResult — go to the resultRatio of geometric means 0.83 95% CI 0.76–0.90Authors' conclusion
An automated real-time clinical decision support tool resulted in clinically significant reductions in oxycodone prescribed at discharge.
Study context
- Population
- Adult surgical inpatients hospitalized ≥24 h with no opioids in the 24 h before discharge
- Participants
- 10,422 vs 11,795
- Comparison
- Postintervention vs preintervention discharges
- Before interventionn = 10,422reference
- After interventionn = 11,795
- Outcome
- Discharge oxycodone in morphine milligram equivalents (MME)
Methodological detailssegmented regression, adjusted for confounders, systemwide
- Segmented regression
- Adjusted for confounders
- Systemwide
Main finding
Discharge oxycodone MME
Ratio of geometric means
0.83
95% CI 0.76–0.90
P < 0.001
By group
After intervention vs before intervention
ratio of geometric means 0.83 (95% CI 0.76–0.90); P < 0.001
As reported in the abstract
- No difference in slopes
- P = 0.919
Secondary outcomes
| Outcome | Before intervention | After intervention | Estimate | |
|---|---|---|---|---|
| Any oxycodone prescribed at dischargeLevel change | 21% | 18% | RR 0.87 (95% CI 0.79–0.96) | |
| MME among discharges with a prescription | median 112 (quartile 1, quartile 3 75–150) MME | median 75 (quartile 1, quartile 3 38–112) MME | ratio of geometric means 0.70 (95% CI 0.65–0.75) | |
| 0.512Ratio (log scale) |
Original publication
Clinical Decision Support to Reduce Opioid Prescribing at Discharge for Inpatients Undergoing Surgery (LESS Study): An Interrupted Time Series Analysis. Anesthesiology. Published 21 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →