Clinical evaluation of the BioFire Respiratory Pathogen Panel for the guidance of empirical antimicrobial therapy in critically ill patients with hospital-acquired pneumonia: A multicenter, quality improvement project
Authors' conclusion
Implementation of Rapid Multiplex PCR to guide empirical antimicrobial therapy for critically ill patients with HAP was not associated with better outcomes.
Study context
- Population
- Adults on invasive mechanical ventilation with hospital-acquired pneumonia (HAP), 3 ICUs in 2 hospitals in France
- Participants
- 443 adults · 3 ICUs · 2 hospitals
- Comparison
- Multiplex PCR-guided antimicrobial protocol vs European guidelines
- Pre-interventionn = 220reference
- Interventionn = 223
- Outcome
- Composite of:
- Mortality on day 28
- Clinical cure between days 7 and 10
- Duration of invasive mechanical ventilation on day 28 (DOOR analysis)
- Follow-up
- Day 28
Methodological detailsbefore–after, multicentre, pre-intervention vs intervention periods, DOOR analysis, Adherence to stewardship was low
- Before–after
- Multicentre
- Pre-intervention vs intervention periods
- DOOR analysis
- Adherence to stewardship was low
Main finding
As reported in the abstract
Primary composite outcome (DOOR ranking)
No difference in the ranking of the primary composite outcome; DOOR
50.3%
95% CI 49.9%–50.8%
Further findings
Time to efficient antimicrobial treatment
P = 0.56
| Outcome | Pre-intervention | Intervention | P value |
|---|---|---|---|
| Invasive mechanical ventilation-free days · day 28Spread printed in brackets, kind not named | 10.0 (range 0.0–19.0) | 9.0 (range 0.0–20.0) days | P = 0.95 |
Original publication
Clinical evaluation of the BioFire Respiratory Pathogen Panel for the guidance of empirical antimicrobial therapy in critically ill patients with hospital-acquired pneumonia: A multicenter, quality improvement project. Anaesth Crit Care Pain Med. Published 12 February 2024. doi:10.
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