ICU sedation, delirium & recovery

Clinical features and treatments of VEXAS syndrome in critical care: a scoping review

Crit CarePublished Scoping review

Authors' conclusion

This review revealed the lack of systematically analyzed studies focusing on VEXAS syndrome in the critical care setting, suggesting a significant gap in understanding the clinical characteristics and optimal treatments for VEXAS syndrome.

Study context

Population
Patients with VEXAS syndrome requiring critical care78 reports
Participants
55 patients
Outcome
Clinical features and outcomes of critically ill patients with VEXAS syndrome
Methodological detailsPRISMA-ScR guidelines, Joanna Briggs Institute methodology, Cochrane CENTRAL, MEDLINE via PubMed, EMBASE, Web of Science searched May 19, 2024
  • PRISMA-ScR guidelines
  • Joanna Briggs Institute methodology
  • Cochrane CENTRAL, MEDLINE via PubMed, EMBASE, Web of Science searched May 19, 2024

Main finding

As reported in the abstract

Median age (55 cases)

69

Male (of 55 cases)

54 of 55

ICU admission rates

28 to 33%

Mortality rates

18 and 40%

Safety

Infectious complications

Frequently reported with immunosuppressive and immunomodulatory therapies

Original publication

Clinical features and treatments of VEXAS syndrome in critical care: a scoping review. Crit Care. Published 17 April 2025. doi:10.1186/s13054-025-05390-y

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