Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study
Authors' conclusion
The hypothesis was verified that MAP was associated with clinical delivery of MAC ratio.
Study context
- Population
- Cases under general anesthesia with volatile anesthetic
- Participants
- 30,125 cases
- Outcome
- Mean age-adjusted MAC ratio during the maintenance phase of anesthesia; primary exposure mean MAP
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Age-adjusted MAC ratio and its association with MAP
Mean ± SD age-adjusted minimum alveolar concentration (MAC) ratio
1.066 ± 0.173
Mean ± SD mean arterial pressure (MAP) (mmHg)
82 ± 10
MAP associated with MAC ratio, overall model: β
0.0028
95% CI 0.0024 to 0.0032P < 0.0001
Observational data: associations, not effects.
Secondary outcomes
Female sex and MAC ratio
- Female sex: β
- −0.0182 (95% CI −0.0219 to −0.0144; P < 0.0001)
- Laboratory, surgical and anesthetic factors also associated with anesthetic agent concentration
Genome-wide association studies of MAC ratio (2 models)
- Variants near 6 genes (DPH6, CPM, EEFSEC, SGSM1, CDH9, DISC1) reaching suggestive threshold (P < 1 × 10 −6) in one but not both models
- 8
- None exceeded genome-wide significance (P < 5 × 10 −8)
- 0
Original publication
Clinical and Genetic Factors Associated with Intraoperative Minimum Alveolar Concentration Ratio: A Single-center Retrospective Cohort and Genome-wide Association Study. Anesthesiology. Published 9 June 2025. doi:10.
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