The Probability Distribution of Times to Awakening From Sevoflurane Anesthesia, Among a Homogeneous Group of Cases With the Same Age-Adjusted Minimum Alveolar Concentration Fraction
Authors' conclusion
A homogeneous patient population had a log-normal distribution of extubation times.
Study context
- Population
- Homogeneous group: oral surgery extractions by 1 surgeon, sevoflurane anesthesia with 0.3 minimum alveolar concentration (MAC) fraction at surgery end, without trainees, N2O, BIS monitor or NMB reversalfrom 182,374 GA cases
- Participants
- 48 participants
- Outcome
- Probability distribution of extubation times (hypothesised log-normal)
Methodological detailscomputer simulation (Gas Man)
- Computer simulation (Gas Man)
Main finding
As reported in the abstract
Distribution of extubation times
- Extubation times followed a log-normal distribution (Shapiro-Wilk W = 0.98)
- P = .68
Observational data: associations, not effects.
Further findings
Simulated awakening times (Gas Man)
- Expected awakening times would appear to be a log-normal distribution, assuming patients differ solely in their awakening threshold of vessel-rich group sevoflurane concentration
Original publication
The Probability Distribution of Times to Awakening From Sevoflurane Anesthesia, Among a Homogeneous Group of Cases With the Same Age-Adjusted Minimum Alveolar Concentration Fraction. Anesth Analg. Published 28 February 2025. doi:10.
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