Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models
Authors' conclusion
The eMAC fraction showed a superior performance in indicating the loss of response to electric stimulus compared to BIS.
Study context
- Population
- Patients receiving GA with a random dose combination of propofol and remifentanil
- Participants
- 53 patients
- Comparison
- eMAC fraction vs BIS
- Outcome
- Prediction probability (Pk) of loss of movement response to tetanic electric stimulus
Main finding
As reported in the abstract
Pk for predicting loss of movement response to tetanic stimulus
eMAC fraction
0. 80
mean · SD 0.06
BIS
0.71
mean · SD 0.07
P < 0.001
Further findings
- eMAC fraction at awakening during emergence
- 0. 30 · mean · SD 0.15
eMAC fraction during maintenance
- eMAC fraction values within 1.3 to 2.6 (all patients)
- ≈71.9%
- Changes related to anesthetic dose and surgical phase
Original publication
Feasibility Study of an Indicator of Equivalent Potency of Multiple Anesthetics Normalized by Minimum Alveolar Concentration Derived From Response Surface Models. Anesth Analg. Published 17 April 2025. doi:10.
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