Effect of Sevoflurane Anesthesia on Diastolic Function: A Prospective Observational Study
Authors' conclusion
In this study, echocardiographic parameters of diastolic function, including septal e', E, E/A, and DT, improved with sevoflurane anesthesia in patients with preexisting diastolic dysfunction, but remained unchanged in patients with normal diastolic function.
Study context
- Population
- Patients undergoing breast surgery or laparoscopic cholecystectomy under sevoflurane (1 to 2 minimum alveolar concentration (MAC), BIS 40 to 50)
- Participants
- 60 patients
- Exposure
- Diastolic dysfunction vs Normal
- Diastolic dysfunctionn = 34
- Normaln = 26reference
- Outcome
- Percentage change of septal e' between pre-anaesthesia TTE and end-of-surgery TTE (under 0.8 to 1 MAC sevoflurane, spontaneous breathing) (Δe')
- Follow-up
- End of surgery
Main finding
As reported in the abstract
Δe'
Diastolic dysfunction
30
median · IQR 6–64 · %
Normal
0
median · IQR −18–11 · %
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
Median, %
| Outcome | Diastolic dysfunction | Normal | P value |
|---|---|---|---|
| ΔLAVI | −15 (IQR −31–-3) | −4 (IQR −20–10) | P = 0.091 |
| ΔE/e' | 11 (IQR −16–26) | 12 (IQR −9–22) | P = 0.853 |
E, E/A and deceleration time (DT)
- Improved significantly in diastolic dysfunction vs normal
TR
- TR minimal in both groups
Original publication
Effect of Sevoflurane Anesthesia on Diastolic Function: A Prospective Observational Study. Anesth Analg. Published 27 February 2024. doi:10.
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