Efficacy of a propofol bolus against placebo to prevent cough at emergence from general anesthesia with desflurane: a randomized controlled trial
Authors' conclusion
In the present trial, a propofol bolus administered at emergence did not reduce the incidence of cough occurring between T0 and T5 following a desflurane-based general anesthesia compared with placebo.
Study context
- Population
- Patients scheduled for elective surgery under desflurane-based GA with "no touch" emergence
- Participants
- 154 patients
- Comparison
- Propofol bolus vs normal saline (NS) at emergence from desflurane GA
- Propofoln = 73
- NSn = 68reference
- Primary endpoint
- Incidence of cough between discontinuation of desflurane (T0) and reaching MACage of 0.15
Methodological detailsplacebo-controlled, prospective
- Placebo-controlled
- Prospective
Primary result
As reported in the abstract
Cough between T0 and MACage 0.15
Regained consciousness before MACage 0.15, NS
27 of 68
40%
Regained consciousness before MACage 0.15, Propofol
13 of 73
18%
Secondary outcomes
Cough incidence and severity until 5 min postextubation (T0-T5)
| Outcome | Mean difference (95% CI) | P value |
|---|---|---|
| Time to extubationProlonged in propofol group | 3 min 27 sec (1 min 7 sec to 4 min 47 sec) | P < 0.001 |
Cough incidence and severity until 5 min postextubation (T0-T5)
- No significant differences between groups
Safety
| Outcome | P value |
|---|---|
| Vasopressor use at emergenceMore vasopressors used in propofol group | P = 0.02 |
Respiratory complications, nausea and vomiting, agitation, sedation
- Not different between groups
Original publication
Efficacy of a propofol bolus against placebo to prevent cough at emergence from general anesthesia with desflurane: a randomized controlled trial. Can J Anaesth. Published 24 February 2023. doi:10.
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