Clinical implication of regional osteopenia in complex regional pain syndrome: a retrospective comparative study
Authors' conclusion
Regional osteopenia in the affected limb can anticipate positive responses to sympathetic blockade when combined with TPBS in early CRPS.
Study context
- Population
- Patients with complex regional pain syndrome (CRPS) who underwent CT of their affected limbs116 analysed
- Participants
- 167 patients
- Exposure
- Early CRPS vs Persistent CRPS
- Outcome
- Prevalence and risk factors of affected-limb regional osteopenia (CT) and its association with response to sympathetic blockade
Methodological detailsmultivariable analysis, ROC curve analysis
- Multivariable analysis
- ROC curve analysis
Main finding
As reported in the abstract
Regional osteopenia (CT)
Observational data: associations, not effects.
Further findings
Risk predictors of regional osteopenia (multivariable)
| OR (95% CI) | ||
|---|---|---|
| Older age | 1.06 (1.02–1.10) | |
| Positive three-phase bone scintigraphy (TPBS) | 3.94 (1.46–10.66) | |
| 0.050.21520Odds ratio (log scale) |
Positive response to sympathetic blockade (multivariable)
| OR (95% CI) | ||
|---|---|---|
| Early phase | 5.49 (1.44–20.88) | |
| Regional osteopenia | 5.11 (1.49–17.53) | |
| Positive TPBS | 6.30 (2.21–17.93) | |
| 0.050.21520Odds ratio (log scale) |
- Positive response to sympathetic blockade (multivariable) — Predicted probability>0.358: sensitivity
- 0.86
- Positive response to sympathetic blockade (multivariable) — Predicted probability>0.358: specificity
- 0.76
- Risk predictors of regional osteopenia (multivariable): adjusted for age, sex, body mass index (BMI) and variables with p values<0.1
- Positive response to sympathetic blockade (multivariable): adjusted for age, sex, BMI and variables with p values<0.1
Original publication
Clinical implication of regional osteopenia in complex regional pain syndrome: a retrospective comparative study. Reg Anesth Pain Med. Published 17 February 2025. doi:10.
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