Perioperative medicine & outcomes
Clinical implications and feasibility of cerebral autoregulation-based precision blood pressure monitoring in major noncardiac surgery: A protocol for AUTOREGULATE-NONCARDIAC, a multicentre prospective cohort study and peri-operative precision medicine platform
Study context
- Population
- Adults ≥45 years at cardiovascular risk undergoing elective major noncardiac surgery with invasive blood pressure (BP) monitoring, surgical time ≥90 min, postoperative hospital stay ≥1 night; 3 Swiss tertiary care centres
- Exposure
- Intra-operative BP excursions below the lower level of cerebral autoregulation (near-infrared spectroscopy (NIRS)-based cerebral autoregulation (cAR) monitoring) and organ injury
- Outcome
- Composite of:
- Peri-operative myocardial injury
- Peri-operative AKI
- Follow-up
- Postoperative days 1 to 3
Methodological detailsprotocol, multicentre, Secondary outcome: composite of major cardiovascular, renal and neurological complications up to 1 year (acute coronary syndrome, acute congestive HF, coronary revascularisation, stroke, new or progressive CKD, new need for RRT, all-cause mortality, cardiovascular mortality)
- Protocol
- Multicentre
- Secondary outcome: composite of major cardiovascular, renal and neurological complications up to 1 year (acute coronary syndrome, acute congestive HF, coronary revascularisation, stroke, new or progressive CKD, new need for RRT, all-cause mortality, cardiovascular mortality)
Main finding
As reported in the abstract
- Results not reported (N/A)
Observational data: associations, not effects.
Original publication
Clinical implications and feasibility of cerebral autoregulation-based precision blood pressure monitoring in major noncardiac surgery: A protocol for AUTOREGULATE-NONCARDIAC, a multicentre prospective cohort study and peri-operative precision medicine platform. Eur J Anaesthesiol Intensive Care. Published 5 December 2025. doi:10.
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