Clinical outcomes during and beyond different COVID-19 critical illness variant periods compared with other lower respiratory tract infections
Authors' conclusion
Overall, COVID-19 critical was associated with an increased hazard of in-hospital mortality, but among those discharged alive from the hospital, less severe long-term outcomes were observed compared with other LRTIs.
Study context
- Population
- Intensive Care Unit (ICU)-admitted adults in Stockholm, Sweden, 1 January 2016 to 15 September 2022
- Participants
- 1,421 / 551 / 190 / 223 / 2,380
- Exposure
- COVID-19 vs other LRTI
- Wild-typen = 1,421
- Alphan = 551
- Deltan = 190
- Omicronn = 223
- LRTIn = 2,380reference
- Outcome
- In-hospital mortality
Methodological detailshealth registries
- Health registries
Main finding
As reported in the abstract
Each group vs LRTIAdjusted cause-specific hazard ratio (95% CI)
Wild-type
1.33(1.16–1.53)
Alpha
1.53(1.28–1.82)
Delta
1.70(1.30–2.24)
Omicron
1.59(1.24–2.02)
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Post-discharge mortality (among discharged alive) · 180 days | LRTI 9% |
- Post-discharge mortality (among discharged alive) — Lower in COVID-19 cohorts
- 1-3%
Hospital readmission (among discharged alive) · 180 days
- Lower in COVID-19 cohorts vs LRTI, cause-specific hazard ratio (CSHRs) ranging
- 0.42 to 0.68
Days alive and at home (DAAH) · 180 days
- All COVID-19 cohorts had more DAAH after vs before the critical illness compared with LRTI
Original publication
Clinical outcomes during and beyond different COVID-19 critical illness variant periods compared with other lower respiratory tract infections. Crit Care. Published 6 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →