Association Between Type of Immunosuppression and the Incidence, Microbiology, and Outcomes of Bacterial Ventilator-Associated Lower Respiratory Tract Infections: A Retrospective Multicenter Study
Main finding · 28-day cumulative incidence of bacterial VALRTIResult — go to the resultAdjusted cause-specific hazard ratio 0.61 95% CI 0.37–0.97Authors' conclusion
Patients with hematologic malignancies had a lower 28-day cumulative incidence of bacterial VALRTI than patients with other types of immunosuppression, mainly due to a lower incidence of ventilator-associated pneumonia.
Study context
- Population
- Immunocompromised adults requiring invasive mechanical ventilation (IMV) for >48 hours, 118 ICUs in 9 countries
- Participants
- 854 adults · 118 ICUs
- Exposure
- Hematologic malignancies vs other types of immunosuppression
- Hematologic malignanciesn = 162
- Outcome
- Cumulative incidence of bacterial ventilator-associated lower respiratory tract infection (VALRTI)
- Follow-up
- 28 days
Methodological detailsmulticentre, international
- Multicentre
- International
Main finding
28-day cumulative incidence of bacterial VALRTI
Adjusted cause-specific hazard ratio
0.61
95% CI 0.37–0.97
By group
Hematologic malignancies vs Other immunosuppression
adjusted cause-specific HR 0.61 (95% CI 0.37–0.97)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Ventilator-associated pneumonia
VALRTI due to multidrug-resistant bacteria
- Proportion similar between groups
Mortality and ICU LOS
- Bacterial VALRTI associated with increased mortality and longer ICU LOS, independent of type of immunosuppression
Original publication
Association Between Type of Immunosuppression and the Incidence, Microbiology, and Outcomes of Bacterial Ventilator-Associated Lower Respiratory Tract Infections: A Retrospective Multicenter Study. Crit Care Med. Published 21 February 2025. doi:10.
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