Neuroanesthesia & neurocritical care
Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury
An erratum to this article was published (JAMA Netw Open, 1 May 2025 ↗)
Authors' conclusion
In this cohort study of children with moderate to severe TBI, the use of HTS was not associated with increased survival or improved functional outcomes compared with mannitol.
Study context
- Population
- Children (<18 years) with moderate to severe traumatic brain injury (TBI) (GCS ≤13) at 28 PICUs in Asia, Latin America and Europe, 2018–2022
- Participants
- 445 children · 28 PICUs
- Exposure
- 3% hypertonic saline (HTS) vs 20% mannitol
- HTSn = 184
- Mannitoln = 82reference
- Both agentsn = 69
- Neither agentn = 110
- Outcome
- Mortality and functional outcomes (discharge PCPC scores, 3-month GOS-E-Peds scores)
Methodological detailsmulticentre, inverse probability of treatment weighting (propensity score)
- Multicentre
- Inverse probability of treatment weighting (propensity score)
Main finding
As reported in the abstract
Mortality
P = 0.34
Observational data: associations, not effects.
Original publication
Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury. JAMA Netw Open. Published 3 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →