Respiratory failure & ventilation
Clinical outcomes in patients undergoing invasive mechanical ventilation using NAVA and other ventilation modes - A systematic review and meta-analysis
Pooled resultResult — go to the resultMD 3.42 95% CI 1.21–5.62Authors' conclusion
NAVA mode has a modest impact on MV-free days and weaning success, with no association with improvements in other relevant clinical outcomes.
Study context
- Population
- Critically ill adults admitted to the ICU with invasive mechanical ventilation (MV)
- Participants
- 643 adults · 5 randomized clinical trials (RCTs)
- Comparison
- NAVA vs standard ventilation mode
- Outcome
- Ventilatory free-days (VFD)
- Follow-up
- 28 days
Pooled result
As reported in the abstract
MD
3.42
95% CI 1.21–5.62
NAVA vs Control
MD 3.42 (95% CI 1.21–5.62)
Further pooled results
| Outcome | OR (95% CI) | |
|---|---|---|
| ICU mortalityI2 = 41% | 0.58 (0.33–1.03) | |
| Weaning failureI2 = 0% | 0.51 (0.29–0.88) | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | MD (days) (95% CI) | |
|---|---|---|
| Number of MV daysI2 = 0% | −1.9 (−4.2 to 0.3) | |
| −6−4−202Difference, days (linear scale) |
Original publication
Clinical outcomes in patients undergoing invasive mechanical ventilation using NAVA and other ventilation modes - A systematic review and meta-analysis. J Crit Care. Published 21 March 2023. doi:10.
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