Respiratory failure & ventilation
Clinical Performance of Spo 2/Fio 2 and Pao 2/Fio 2 Ratio in Mechanically Ventilated Acute Respiratory Distress Syndrome Patients: A Retrospective Study
Authors' conclusion
Sp o2 /F io2 ratio can detect oxygenation impairment and classify ARDS severity similarly to Pa o2 /F io2 ratio in a more rapid and handy way, even during a PEEP trial.
Study context
- Population
- Mechanically ventilated patients with acute respiratory distress syndrome (ARDS), medical-surgical ICU, already enrolled in previous studiesmechanically ventilated
- Participants
- 258 participants
- Exposure
- SpO2/FiO2 ratio vs PaO2/FiO2 ratio for ARDS severity classification
- Outcome
- Agreement in classifying ARDS severity, Sp o2 /F io2 vs Pa o2 /F io2 ratio
Methodological detailssingle ICU (medical-surgical), CT-based lung recruitability, positive end-expiratory pressure (PEEP) trial
- Single ICU (medical-surgical)
- CT-based lung recruitability
- PEEP trial
Main finding
As reported in the abstract
Sp o2 /F io2 and Pa o2 /F io2 ratio: moderate agreement in classifying ARDS severity (intraclass correlation coefficient)
0.63
Observational data: associations, not effects.
Further findings
| Outcome | Sp o2 /F io2 ratio |
|---|---|
| Detection of venous admixture >20% | 89% |
| Threshold | less than 235 |
Association between Sp o2 /F io2 and Pa o2 /F io2
- Nonlinear association between Sp o2 /F io2 and Pa o2 /F io2; arterial pH and Pa co2 had no confounding effect
Detection of venous admixture >20%
- Sp o2 /F io2 ratio less than 235 detected patients with venous admixture greater than 20% similarly to a Pa o2 /F io2 ratio less than 200
Respiratory mechanics, gas exchange, lung radiological characteristics, ICU mortality between correspondent severity classes
- No difference between correspondent classes by Sp o2 /F io2 vs Pa o2 /F io2 ratio-derived classifications, also within two levels of PEEP
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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