Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron sublineage JN.1 in critically ill COVID-19 patients: a prospective, multicenter cohort study in France, November 2022 to January 2024
Authors' conclusion
Compared with XBB, JN.1 infection was not associated with higher day-28 mortality.
Study context
- Population
- Adults admitted to 40 French ICUs for acute respiratory failure with reverse transcriptase-polymerase chain reaction (RT-PCR)-confirmed SARS-CoV-2 infection, November 2022–January 202440 French ICUs
- Participants
- 56 vs 126
- Exposure
- JN.1 vs XBB sublineage infection
- JN.1n = 56
- XBBn = 126reference
- Outcome
- Day-28 mortality
- Follow-up
- Day 28
Methodological detailsmulticentre, observational, substudy of the SEVARVIR cohort
- Multicentre
- Observational
- Substudy of the SEVARVIR cohort
Main finding
As reported in the abstract
Adjusted odds ratio
1.06
95% CI 0.17–1.42
P = 0.19
By group
JN.1 vs XBB
aOR 1.06 (95% CI 0.17–1.42); P = 0.19
Observational data: associations, not effects.
Further findings
| Outcome | JN.1 | XBB | P value |
|---|---|---|---|
| ECMO during ICU stay | 1.8% | 0 events | P = 0.30 |
| Events/total | — not stated in the abstract | 0/126 |
— not stated in the abstract
Obesity (baseline phenotype)
- JN.1-infected patients more likely obese than others: 35.7% vs 20.8%
- P = 0.033
Immunosuppression (baseline phenotype)
- JN.1-infected patients less frequently immunosuppressed than others: 20.4% vs 41.4%
- P = 0.010
Supportive care and treatments in JN.1-infected patients
- Invasive mechanical ventilation
- 29.1%
- Dexamethasone (among those ventilated)
- 87.5%
- Tocilizumab
- 14.5%
- Monoclonal antibodies
- 0
ICU LOS
- No significant between-group difference in ICU LOS: 6.0 [3.5;11.0] vs 7.0 [4.0;14.0] days
- P = 0.21
Original publication
Clinical phenotypes and outcomes associated with SARS-CoV-2 Omicron sublineage JN.1 in critically ill COVID-19 patients: a prospective, multicenter cohort study in France, November 2022 to January 2024. Ann Intensive Care. Published 28 June 2024. doi:10.
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