Respiratory failure & ventilation
Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes
Authors' conclusion
Composition of lower airway microbiota (both microbiota and mycobiota) differs between influenza, COVID-19 and bacterial CAP-related ARDS.
Study context
- Population
- Consecutive acute respiratory distress syndrome (ARDS) patients (Berlin classification) requiring invasive ventilation, with influenza, SARS-CoV-2 or bacterial infection
- Participants
- 53 patients
- Exposure
- COVID-19 vs Influenza vs Bacterial CAP
- COVID-19n = 24reference
- Influenzan = 18
- Bacterial CAPn = 11
- Outcome
- Lower airway microbiota composition (endotracheal aspirate, V3-V4 and ITS2 sequencing)
- Follow-up
- Admission
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Bacteriobiota and mycobiota composition (β-diversity) across the three groups
- Bacteriobiota β-diversity dissimilar between the three groups
- p = 0.05
- Mycobiota β-diversity dissimilar between the three groups
- p = 0.01
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Bacterial α-diversityBacterial CAP vs COVID-19 · significantly lower in bacterial CAP-related ARDS | P = 0.04 |
| Lung mycobiota α-diversityInfluenza vs COVID-19 · higher in influenza-related ARDS | P = 0 < 01 |
Original publication
Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes. Crit Care. Published 22 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →