ICU sedation, delirium & recovery
Clinical Presentation, Laboratory Abnormalities, and Predictors of Outcome in 103 Patients With Acute Paraquat Poisoning: A Prospective Observational Study
Authors' conclusion
Paraquat is a lethal poison associated with a high mortality.
Study context
- Population
- Patients admitted to medicine wards and medical ICU with acute paraquat self-poisoning, tertiary care teaching hospital, August 2023 to March 2024
- Participants
- 103 consecutive patients
- Exposure
- Patients who died vs survivors
- Diedn = 78
- Outcome
- Mortality
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Patients who died
75.7%
Observational data: associations, not effects.
Further findings
Amount of poison consumed · univariate analysis
P < 0.001
Serum creatinine · univariate analysis
P < 0.001
Serum bilirubin · univariate analysis
P < 0.001
Median
| Outcome | Died | Survivors | P value |
|---|---|---|---|
| APACHE II scoreUnivariate analysis | 15.5 (IQR 12–19) | 7 (IQR 3.5–11) | P < 0.001 |
| PaO2/FiO2 ratio at admissionUnivariate analysis | 300 (IQR 150–400) | 420 (IQR 396–485) | P < 0.001 |
Mortality by IPCS Poisoning Severity Score grade
- Increasing trend in mortality with increasing grade
- P = 0.001
Independent predictors of mortality (multivariable analysis)
- Shortness of breath, OR
- 0.008; p = 0.072
- Hepatic dysfunction, OR
- 0.012; p = 0.048
- Duration of hospital stay, OR
- 1.030; p = 0.023
- Infiltrates on chest radiograph/CT chest, OR
- 0.003; p = 0.011
- Reported by authors as significant independent predictors
Presenting symptoms
- Vomiting
- 93%
- Throat pain
- 85%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Clinical Presentation, Laboratory Abnormalities, and Predictors of Outcome in 103 Patients With Acute Paraquat Poisoning: A Prospective Observational Study. Crit Care Med. Published 30 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →