Clinical significance of thrombocytopenia in patients with septic shock: An observational retrospective study
Authors' conclusion
Severe thrombocytopenia was independently associated with ICU mortality and increased risk of bleeding, but not with infectious and thrombotic events.
Study context
- Population
- Patients with septic shock, 2008–2019
- Participants
- 1,024 patients
- Exposure
- Severe, mild or relative thrombocytopenia vs no thrombocytopenia
- Outcome
- ICU mortality and ICU-acquired complications (severe bleeding, infections, thrombotic events)
- Follow-up
- During the ICU stay
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
ICU-acquired bleeding events
P < 0.001
- In-ICU mortality rate (all patients)
- 27%
- Thrombocytopenia occurrence: severe / mild / relative
- 33%, 40% and 9%
- Intensive care unit (ICU)-acquired infections / hemorrhagic / thrombotic complications (all patients)
- 27.5%, 13.3% and 11.6%
Observational data: associations, not effects.
Further findings
ICU-acquired infections — Thrombocytopenia categories vs Non-thrombocytopenic
P < 0.001
ICU-acquired thrombotic events — Thrombocytopenia categories vs Non-thrombocytopenic
P = 0.03
Original publication
Clinical significance of thrombocytopenia in patients with septic shock: An observational retrospective study. J Crit Care. Published 28 March 2023. doi:10.
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