Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study
Authors' conclusion
CDI was uncommon, severity was mild to moderate and not associated with mortality however CDI was associated with a longer hospital stay.
Study context
- Population
- Mechanically ventilated critically ill patients
- Participants
- 2,650 participants
- Exposure
- Clostridioides difficile infection (CDI) vs no CDI
- CDIn = 86
- Outcome
- CDI incidence, prevalence, timing, severity, predictors and outcomes
Methodological detailsnested within a randomised trial of Lactobacillus rhamnosus GG vs placebo
- Nested within a randomised trial of Lactobacillus rhamnosus GG vs placebo
Main finding
As reported in the abstract
CDI incidence and prevalence
- Patients diagnosed with CDI
- 86
- Incidence (during 90,833 hospital-days)
- 0.95/1000 hospital-days
- CDI prevalence
- 3.2%
- CDI pre-ICU
- 0.3%
- CDI in the ICU
- 2.2%
- CDI post-ICU
- 0.8%
- Relapse or recurrence of CDI
- 9.3%
Observational data: associations, not effects.
Further findings
Risk factors for CDI
- No risk factors for CDI identified
Hospital mortality
- CDI not associated with hospital mortality
Duration of hospital stay
- Longer with CDI vs without CDI
Safety
Complications of CDI
- Septic shock
- 26.7%
- Organ failure
- 16.3%
- Toxic megacolon requiring colectomy
- 1.2%
Original publication
Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study. J Crit Care. Published 20 January 2023. doi:10.
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