Respiratory failure & ventilation
Clustering COVID-19 acute respiratory distress syndrome (ARDS) patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort
Authors' conclusion
During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve.
Study context
- Population
- Patients admitted to ICU with COVID-19-related ARDS in Spain (CIBERESUCICOVID cohort)of 6205 patients
- Participants
- 3,743 patients
- Exposure
- Cluster 2 vs cluster 1, at baseline and on day 3
- Outcome
- 90-day mortality by cluster
- Follow-up
- 90 days
Methodological detailscluster analysis, k-prototypes clustering
- Cluster analysis
- K-prototypes clustering
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Cluster membership · day 3
Patient characteristics by cluster · baseline and day 3
- Cluster 2 older, more often hypertensive, more shock, organ dysfunction and inflammatory biomarkers, worst respiratory indexes at both time points
Change of cluster from baseline to day 3
- Patients clustered in the first group at baseline re-clustered in the second group on day 3
- 458 (33%)
- Patients clustered in the second group at baseline re-clustered in the first group on day 3
- 638 (27%)
Original publication
Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort. Crit Care. Published 21 March 2024. doi:10.
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