Respiratory failure & ventilation
Phenotypic characterization of patients with ANCA-associated vasculitis and diffuse alveolar hemorrhage: a data-driven analysis of a multicentre, retrospective, nationwide cohort
Authors' conclusion
This large ICU cohort highlights three clinically relevant phenotypes of AAV-related DAH, which could inform the development of phenotype-driven immunosuppressive strategies.
Study context
- Population
- Patients in the ICU with severe ANCA-associated vasculitis-related diffuse alveolar hemorrhage (respiratory symptoms with new infiltrates consistent with alveolar hemorrhage, along with oxygen saturation ≤85%, high-flow oxygen or mechanical ventilation requirement), 2012–2024patients with severe ANCA-associated vasculitides (AAV)-related diffuse alveolar hemorrhage (DAH) included (66 years old, 52% female)
- Participants
- 197 patients
- Exposure
- Clusters compared regarding organ involvement, severity, management, and mortality at 30 and 90 days
- Outcome
- Renal replacement therapy
Methodological detailsKohonen self-organizing maps, data-driven
- Kohonen self-organizing maps
- Data-driven
Main finding
As reported in the abstract
MPO pulmonary-renal (MPO-PR)
73%
Observational data: associations, not effects.
Further findings
Mortality · 30 days
| Outcome | MPO-PR | Mild-R | PR3-MO |
|---|---|---|---|
| Invasive mechanical ventilation | 71% | — not stated in the abstract | 68% |
— not stated in the abstract
Invasive mechanical ventilation
- Most common in the MPO-PR and PR3 multi-organ (PR3-MO) groups
Mortality · 30 days
- Thirty-day mortality differed significantly
Clinical phenotypes
- Marked clinical heterogeneity; three phenotypes emerged
Original publication
Phenotypic characterization of patients with ANCA-associated vasculitis and diffuse alveolar hemorrhage: a data-driven analysis of a multicentre, retrospective, nationwide cohort. Ann Intensive Care. Published 5 October 2026. doi:10.
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