Respiratory failure & ventilation
Derivation and validation of generalized sepsis-induced acute respiratory failure phenotypes among critically ill patients: a retrospective study
Authors' conclusion
The phenotypes demonstrated unique patterns of organ injury and differences in clinical outcomes
Study context
- Population
- ICU patients with sepsis who required mechanical ventilation for ≥ 24 h, two high-volume academic hospital centersderivation MICU Hospital-I (N = 3225)
- Exposure
- A vs B vs C vs D
- Outcome
- Derivation of sepsis-induced ARF phenotypes and their generalizability
Methodological detailsmulticentre, explainable machine learning-based clustering, external validation
- Multicentre
- Explainable machine learning-based clustering
- External validation
Main finding
As reported in the abstract
ARF phenotypes
- Four distinct acute respiratory failure (ARF) phenotypes identified (A–D)
- Phenotypes reproduced in external validation (MICU Hospital-II, N = 848; SICU Hospital-I, N = 1112; SICU Hospital-II, N = 465)
- Differences in clinical course and mortality rates despite similar demographics and admission co-morbidities
Observational data: associations, not effects.
Further findings
28-day mortality (Kaplan-Meier)
- Significant difference across the phenotypes, consistent across MICU and SICU of both hospitals
- P < 0.01
Treatment effect of high positive end-expiratory pressure (PEEP) strategy
- Phenotypes demonstrated differences in treatment effects associated with high PEEP strategy
Original publication
Derivation and validation of generalized sepsis-induced acute respiratory failure phenotypes among critically ill patients: a retrospective study. Crit Care. Published 1 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →