Respiratory failure & ventilation
Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores
Authors' conclusion
P/F ratio cutoffs using 10 kPa (75 mmHg) intervals were identified to be optimal for distinguishing stages of respiratory failure severity.
Study context
- Population
- ICU patients, Kuopio University Hospital, Finland (derivation) and eICU multicentre US registry (validation)
- Exposure
- Derived P/F ratio cutoffs vs current respiratory Sequential Organ Failure Assessment (SOFA) score cutoffs
- Outcome
- Discrimination for hospital mortality (optimal P/F ratio cutoffs)
Methodological detailscutoff derivation and external validation, single-centre derivation cohort, multicentre validation registry
- Cutoff derivation and external validation
- Single-centre derivation cohort
- Multicentre validation registry
Main finding
As reported in the abstract
Discrimination for hospital mortality in validation cohort
| Group | AUROC | 95% CI |
|---|---|---|
| Derived cutoffs | 0.615 | 0.607-0.622 |
| Current respiratory SOFA | 0.610 | 0.603-0.618 |
AUROC
Derived cutoffs0.615
Current respiratory SOFA0.610
95% CI
Derived cutoffs0.607-0.622
Current respiratory SOFA0.603-0.618
- Derived cutoffs vs Current respiratory SOFA: P < 0.001
- Clear separation of severity categories (chi-square for log-rank statistic)
- 356.9
Observational data: associations, not effects.
Further findings
- Advanced respiratory support associated with higher mortality; inclusion as prerequisite improved discrimination only in moderate category, not severe or critical
Original publication
Optimal Cutoffs for the Ratio of Arterial Oxygen Partial Pressure to Inspired Oxygen Fraction in Categorizing Respiratory Impairment Severity in Organ Failure Scores. Acta Anaesthesiol Scand. Published 29 October 2025. doi:10.
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