Respiratory failure & ventilation
External validation of the ISARIC 4C Mortality Score to predict in-hospital mortality among patients with COVID-19 in a Canadian intensive care unit: a single-centre historical cohort study
Authors' conclusion
The ISARIC 4C Mortality Score is a tool that had a good predictive performance for in-hospital mortality in a cohort of patients with COVID-19 admitted to an ICU for respiratory failure.
Study context
- Population
- Consecutive patients admitted with COVID-19-associated respiratory failure to a university-affiliated, intensivist-staffed intensive care unit (ICU) (Montreal, Canada), 5 March 2020 to 5 March 2022102 (23.8%) died in hospital
- Participants
- 429 patients
- Exposure
- ISARIC 4C Mortality Score vs Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation (APACHE) II scores
- Outcome
- In-hospital mortality (discrimination of the ISARIC 4C Mortality Score, AUC)
Methodological detailssingle-centre, external validation, historical cohort
- Single-centre
- External validation
- Historical cohort
Main finding
As reported in the abstract
Discrimination for in-hospital mortality (AUC)
ISARIC 4C
0.762
AUC · 95% CI 0.717–0.811
SOFA
0.705
AUC · 95% CI 0.648–0.761
APACHE II
0.722
AUC · 95% CI 0.667–0.777
Observational data: associations, not effects.
Original publication
External validation of the ISARIC 4C Mortality Score to predict in-hospital mortality among patients with COVID-19 in a Canadian intensive care unit: a single-centre historical cohort study. Can J Anaesth. Published 8 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →