Respiratory failure & ventilation
Escalation of Oxygenation Modalities and Mortality in Critically Ill Immunocompromised Patient With Acute Hypoxemic Respiratory Failure: A Clustering Analysis of a Prospectively Multicenter, Multinational Dataset
Authors' conclusion
This study identified three distinct highly performing clusters of response to initial oxygenation strategy, which reliably predicted the need for iMV requirement and hospital mortality.
Study context
- Population
- Critically ill immunocompromised patients admitted to ICU for acute respiratory failure, not requiring invasive mechanical ventilation (iMV) at ICU admission
- Participants
- 1,547 participants
- Comparison
- Clusters of change in oxygenation modality over time
- Cluster An = 717reference
- Cluster Bn = 499
- Cluster Cn = 331
Methodological detailspost hoc analysis, longitudinal K-mean clustering, multinational, observational prospective
- Post hoc analysis
- Longitudinal K-mean clustering
- Multinational
- Observational prospective
Primary result
As reported in the abstract
Need for iMV
Each group vs cluster AOdds ratio (95% CI)
Cluster B
9.87(7.26–13.50)
Cluster C
19.8(13.7–29.1)
Further findings
| Outcome | Cluster B | Cluster C |
|---|---|---|
| ICU mortality | 97% | 0.3% |
ICU mortality
- Cluster A: high survival rate
Original publication
Escalation of Oxygenation Modalities and Mortality in Critically Ill Immunocompromised Patient With Acute Hypoxemic Respiratory Failure: A Clustering Analysis of a Prospectively Multicenter, Multinational Dataset. Crit Care Med. Published 27 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →