Impact of early PaCO2 and pH fluctuations on neurological outcomes in acute respiratory distress syndrome (ARDS) patients receiving VV ECMO: a retrospective cohort study from the Chinese Society of Extracorporeal Life Support (CSECLS) registry
Authors' conclusion
Excessive reductions in PaCO2 during the early initiation of VV ECMO, rather than pH elevation, were associated with an increased risk of neurological complications in ARDS patients.
Study context
- Population
- Adult ARDS patients who underwent VV ECMO, January 2018–December 2022, CSECLS Registry
- Participants
- 983 patients
- Exposure
- Clusters of early absolute PaCO2 and pH change at VV ECMO initiation
- Outcome
- Neurological complications
Methodological detailsregistry-based, K-means clustering
- Registry-based
- K-means clustering
Main finding
As reported in the abstract
- Overall incidence of neurological complications
- 2.95%
Observational data: associations, not effects.
Original publication
Impact of early PaCO2 and pH fluctuations on neurological outcomes in ARDS patients receiving VV ECMO: a retrospective cohort study from the CSECLS registry. Ann Intensive Care. Published 25 September 2025. doi:10.
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