Trauma & major bleeding

Coagulopathy correlates with muscle titin injury in critically ill patients

J Crit CarePublished Post-hoc analysis of an observational study

Authors' conclusion

Coagulopathy correlated with muscle titin fragmentation, as an independent risk factor.

Study context

Population
Critically ill patients
Participants
111 patients
Comparison
JAAM-DIC vs no JAAM-DIC
Primary endpoint
Mean N-titin/Cre measured on days 1, 3, 5 and 7

Primary result

As reported in the abstract

Mean N-titin/Cre
  • Mean N-titin/Cre significantly higher in the JAAM-DIC group
  • JAAM-DIC an independent risk factor for mean N-titin/Cre in multivariable analysis; other severity scores were not

Original publication

Coagulopathy correlates with muscle titin injury in critically ill patients. J Crit Care. Published 22 December 2022. doi:10.1016/j.jcrc.2022.154234

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